Npgrj_ni_1505 1060..1066
نویسندگان
چکیده
Of the many dendritic cell (DC) subsets, DCs expressing the monomorphic coreceptor CD8 a-chain (CD8a) are localized permanently in lymphoid organs, whereas ‘tissue-derived DCs’ remain in nonlymphoid tissues until they ‘capture’ antigen and then move to local lymph nodes. Here we show that after lung infection, both naive and memory CD8+ ‘killer’ T cells responded to influenza virus antigens presented by lymph node–resident CD8a+ DCs, but only naive cells responded to antigens presented by lung-derived DCs. This difference provides a mechanism for priming naive T cell responses in conditions in which robust memory predominates. Our findings have implications for immunity to pathogens that can mutate their T cell epitopes, such as influenza virus and human immunodeficiency virus, and challenge the long-held view that memory T cells have less-stringent requirements for activation than naive T cells have.
منابع مشابه
Greater and lesser powers of tort reform: the primary jurisdiction doctrine and state-law claims concerning FDA-approved products.
INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1039 R I. THE PRIMARY JURISDICTION DOCTRINE . . . . . . . . . . . . . . . . . . . . 1043 R II. CONSTITUTIONAL CONSTRAINTS IN FEDERAL-COURT LITIGATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1048 R A. Article III Constraints . . . . . . ...
متن کاملInhibitory effect of heparin on herpes simplex virus.
Nahmias, André J. (Boston University School of Medicine, Boston, Mass.), and Sidney Kibrick. Inhibitory effect of heparin on herpes simplex virus. J. Bacteriol. 87:1060-1066. 1964.-A substance inhibitory to herpes simplex virus was observed during experiments with leukocyte cultures. The component in the cultures responsible for this inhibition was identified as heparin. The minimal inhibitory ...
متن کاملVentricular tachycardia and cardiac sarcoidosis: correspondence between MRI and electrophysiology.
ventricular remodeling with carvedilol in patients with congestive heart failure due to ischaemic heart disease. Australia–New Zealand heart failure research collaborative group. J Am Coll Cardiol 1997; 29:1060–1066. 31. Bristow MR, Gilbert EM, Abraham WT, Adams KF, Fowler MB, Hershberger RE, Kubo SH, Narahara KA, Ingersoll H, Krueger S, Young S, Shusterman N. Carvedilol produces dose-related i...
متن کاملبررسی ویژگیهای جمعیتشناختی و شاخصهای عملکرد کلیوی بیماران با مسمومیت حاد ترامادول در بیمارستان آیتا... طالقانی ارومیه
Background & Aims: Since acute tramadol poisoning is related to several clinical complications. The aim of this study was to evaluate the epidemiologic, demographic and renal function indices in acute tramadol intoxicated patients.Materials & Methods: In this retrospective descriptive study, all patients admitted to Taleghani hospital of Urmia, Iran, were evaluated during a one-year period. Pa...
متن کامل